Charles Robin

A tardigrade cytochrome P450 perturbs Drosophila melanogaster development

The paper shows that a tardigrade cytochrome P450 gene disrupts Drosophila melanogaster development when expressed ubiquitously.

Before the Black Box

The paper investigates evolutionary changes in three enzymes involved in ecdysteroid synthesis across arthropods and correlates these changes with dietary factors.

The haplolethal gene wupA of Drosophila exhibits potential as a target for an X-poisoning gene drive

The paper investigates a gene drive targeting the wupA gene in Drosophila to skew sex ratios, finding it can reduce female progeny and is effective across multiple species.

Phylogenomics of the ecdysteroid kinase-like (EcKL) gene family in insects highlights roles in both steroid hormone metabolism and detoxification

This paper performs phylogenomic analyses of the EcKL gene family in 140 insect genomes, revealing its role in steroid hormone metabolism and detoxification, with functional shifts linked to host plant diversity.

Genetic characterisation of candidate ecdysteroid kinases in Drosophila melanogaster

This study investigates the function of two ecdysteroid kinase-like genes in Drosophila melanogaster using genetic approaches, finding that they may not directly inactivate ecdysteroids but could have novel roles in development.

Acetylcholine esterase of Drosophila melanogaster: a laboratory model to explore applications of insecticide susceptibility gene drives

This paper develops a laboratory model using Drosophila melanogaster to study insecticide susceptibility gene drives, showing they can revert resistance but face challenges like gene drive resistance and population suppression.

Low doses of the organic insecticide spinosad trigger lysosomal defects, ROS driven lipid dysregulation and neurodegeneration in flies

This study shows that low doses of spinosad cause lysosomal defects, oxidative stress, lipid dysregulation, and neurodegeneration in Drosophila.

Ecdysteroid kinase-like (EcKL) paralogs confer developmental tolerance to caffeine in Drosophila melanogaster

This study identifies EcKL genes in Drosophila melanogaster as detoxification enzymes involved in caffeine and kojic acid tolerance through functional validation and genetic analysis.

Identifying candidate detoxification genes in the ecdysteroid kinase-like (EcKL) and cytochrome P450 gene families in Drosophila melanogaster by integrating evolutionary and transcriptomic data

The paper identifies candidate detoxification genes in Drosophila by integrating evolutionary and transcriptomic data, finding that EcKLs may function in detoxification and that many P450s are potential detoxification candidates.

Cis and trans-acting variants contribute to survivorship in a naive Drosophila melanogaster population exposed to ryanoid insecticides

The paper identifies cis and trans-acting genetic variants affecting survivorship in Drosophila melanogaster exposed to ryanoid insecticides.

Structural variants and selective sweep foci contribute to insecticide resistance in the Drosophila melanogaster genetic reference panel

The paper links insecticide resistance in Drosophila melanogaster to structural variants and selective sweep loci using genome-wide association studies.