Zhongyuan Zuo

This study shows that knocking out alpha2 spectrin in postnatal outer hair cells leads to a dissociation of prestin's gating charge movement from electromotility and structural changes in the SSC and plasma membrane-SSC space.

This study identifies CK2-dependent phosphorylation of Daam2 as a regulatory mechanism controlling oligodendrocyte development and myelin repair through Wnt signaling.

This study shows that loss of MECR causes elevated ceramide levels and impaired iron metabolism, linking mitochondrial fatty acid synthesis to neurodegeneration.

The paper identifies ceramide accumulation, lysosomal expansion, and mitochondrial defects as root causes of INAD/PARK14 and tests therapeutic strategies including drugs and gene therapy.

The paper develops new CRISPR-based constructs for Drosophila gene tagging, enabling efficient gene modification with a 70-80% success rate regardless of exon-intron structure.

This study shows that low doses of spinosad cause lysosomal defects, oxidative stress, lipid dysregulation, and neurodegeneration in Drosophila.

The paper introduces three simplified CRISPR-based methods for DNA insertion in Drosophila, using short homology arms and ssDNA/dsDNA donors to generate transgenic constructs efficiently.

The paper investigates how inhibitory molecular layer interneurons influence Purkinje cell firing properties in mice by selectively depleting GABAergic neurotransmission from stellate or basket cells.

The paper introduces two new genetic tools for efficiently tagging genes in Drosophila using MiMIC and CRISPR, enhancing integration efficiency and enabling precise gene manipulation.

This study identifies damaging variants in IRF2BPL associated with neurological phenotypes in humans and shows functional conservation in fruit flies.