Urtė Neniškytė

This study shows that reprogrammed gRNAs with mismatches can shift editing outcomes to improve gene knockout efficiency without reducing overall editing efficiency.

This study shows that maternal high-fat diet causes sex- and estrous cycle-specific changes in glial cells of offspring retinas, affecting microglial activity and Muller glial reactivity.

This study examines the postnatal development of electrophysiological properties and synaptic activity in mouse hippocampal CA1 neurons, revealing sex-dependent differences and functional connectivity changes.

This study designs and optimizes lipid nanoparticles for efficient delivery of CRISPR-Cas ribonucleoprotein complexes, showing improved biodistribution and translocation properties in a brain endothelial model.

This study identifies varicose projection astrocytes as a reactive phenotype associated with neuropathology, showing their presence in humans, mice, and tigers and their induction by inflammation.

The paper introduces a RT-qPCR assay to assess mRNA integrity in brain and subcellular samples, showing it outperforms RIN in correlation with housekeeping gene expression.

This study identifies microglia-mediated synaptic remodeling through trogocytosis and filopodia induction in developing hippocampal cultures.