Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice
Hong‐Ru Chen, Hsiao‐Tien Chien Hagar, Kuan-Wei Wang, Stacy Hovde, Hsiao‐Yun Lin, Min-Hsuan Lin, Cheng-Chun Chang, Ching-Yung Wang, Chia-Yen Chen, Emily J. Bian, Melissa Marie Kinkaid, Min‐Hao Kuo, Chia-Yi Kuan
The paper investigates the role of hyperphosphorylated tau oligomers in inducing neurodegeneration by injecting them into non-transgenic mice, finding cognitive deficits and neuron death.
bioRxiv · Mar 10, 2025 · PreprintNeuroscience