Chia-Yen Chen

Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice

The paper investigates the role of hyperphosphorylated tau oligomers in inducing neurodegeneration by injecting them into non-transgenic mice, finding cognitive deficits and neuron death.

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.

Phenome-wide Heritability Analysis of the UK Biobank

This study estimates SNP heritability for 551 traits from the UK Biobank and examines how age, sex, and socioeconomic status affect heritability estimates.

Explicit modeling of ancestry improves polygenic risk scores and BLUP prediction

This paper shows that explicitly modeling genetic ancestry improves polygenic risk scores and BLUP prediction accuracy for complex traits by reducing ancestry-related biases in SNP effect estimation.