Hong‐Ru Chen

Optimizing CRISPR/Cas9 genome editing in primary human hematopoietic cells to advance studies into HIV biology

This study develops a CRISPR/Cas9 platform for editing primary human HSPCs to investigate HIV host factors and their impact on viral infection in vitro and in vivo.

Meningeal neutrophil infiltration drives inflammation-exacerbated pediatric stroke through IL-36γ signaling

This study identifies meningeal neutrophil infiltration and IL-36γ signaling as key drivers of inflammation-exacerbated pediatric stroke.

Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice

The paper investigates the role of hyperphosphorylated tau oligomers in inducing neurodegeneration by injecting them into non-transgenic mice, finding cognitive deficits and neuron death.

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.