Nox4 Mediates Diastolic Function in a Genetic Model of Pitx2 Haploinsufficiency
Sumner L Gardner, Anam Fatima, Faris Abusharkh, Elizabeth Kobeck, Chitra Basu, Francis J. Miller, Vineet Agrawal
This study investigates the role of Nox4 in HFpEF-like remodeling in Pitx2 haploinsufficient mice, finding increased Nox4 expression and improved outcomes with GKT136901 treatment.
bioRxiv · Jul 1, 2026 · PreprintCell Biology