A cysteine-rich domain of the Cryptococcus neoformans Cuf1 transcription factor is required for high copper stress sensing and fungal virulence
Corinna Probst, Chloe Insler, Catherine A. Denning-Jannace, Estefany Y. Reyes, Jonathan L. Messerschmidt, Lukas M. du Plooy, Charles D. Giamberardino, Connie B. Nichols, Yohannes G. Asfaw, Mari L. Shinohara, Katherine J. Franz, J. Andrew Alspaugh
This paper identifies a cysteine-rich motif in CnCuf1 essential for high copper stress sensing in Cryptococcus neoformans, impacting fungal virulence and lung infection patterns.
mBio · Jun 9, 2026Peer-reviewedMicrobiology