Slow transcriptional elongation causes embryonic lethality and perturbs kinetic coupling of long neural genes
Magdalena M. Maslon, Ulrich Braunschweig, Stuart Aitken, Abigail R. Mann, Fiona M. Kilanowski, Chris J. Hunter, Benjamin J. Blencowe, Alberto Rodolfo Kornblihtt, Ian R. Adams, Javier F. Cáceres
This study shows that slow RNAPII elongation causes embryonic lethality and disrupts splicing and gene expression in neural differentiation.
The EMBO Journal · Apr 15, 2019Peer-reviewedMolecular Biology