Magdalena M. Maslon

Slow RNAPII elongation enhances naive-pluripotency rewiring while preserving replication fork speed

The paper shows that slowing RNAPII elongation during cell state transitions enhances naive pluripotency acquisition while maintaining replication fork speed.

Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner

This study shows histone H1 regulates non-coding RNA turnover on chromatin through m6A modification, affecting replication-transcription conflicts.

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

This study shows that SRSF1 shuttling between nucleus and cytoplasm is essential for ciliogenesis and development, as demonstrated by phenotypic defects in a mouse model with nuclear-retained SRSF1.

Identification of a Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum

The paper identifies an ER-localized NMD pathway that regulates the stability of ER-translated mRNAs through the interaction of NBAS and UPF1.

Slow transcriptional elongation causes embryonic lethality and perturbs kinetic coupling of long neural genes

This study shows that slow RNAPII elongation causes embryonic lethality and disrupts splicing and gene expression in neural differentiation.