Benjamin J. Blencowe

This study identifies H2A.Z ubiquitylation as a marker of repressive chromatin by associating it with silenced regions like methylated CpG islands and homopurine/homopyrimidine sequences.

This study shows that TDP-43 and FUS are recruited by the R1810me2s-SMN pathway, and their defects affect RNAPII termination and R-loop accumulation, contributing to neurodegenerative disorders.

The paper shows that human GIGYF2 does not interact with GRB10, challenging the current understanding of their role in disease.

This study identifies ZBTB48 as a regulator of FTO's substrate selectivity by facilitating its binding to m6A/m6Am-containing RNAs, affecting RNA decay and cancer cell growth.

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

This study identifies SARS-CoV-2 N protein interactions with host proteins and mRNAs, showing it attenuates stress granule formation and alters gene expression.

The paper identifies Znf684 as a C2H2-ZnF protein that interacts with Nxf1 and regulates mRNA export by binding to specific mRNAs.

The paper identifies ACE2 as the only common host dependency for SARS-CoV-2 across multiple cell lines, while other host factors are cell line specific.

The paper identifies alternative splicing programs in three germ layers and shows Quaking's role in cardiac mesoderm specification through splicing regulation.

This study shows that slow RNAPII elongation causes embryonic lethality and disrupts splicing and gene expression in neural differentiation.

Whippet efficiently detects and quantifies alternative splicing, revealing extensive transcriptomic complexity and higher prevalence in tumors.