Javier F. Cáceres

This study identifies SEC13 as a novel NMD factor in mammalian cells and shows its role in regulating ER stress through the UPR pathway.

This study shows histone H1 regulates non-coding RNA turnover on chromatin through m6A modification, affecting replication-transcription conflicts.

This study identifies DHX34 as a dual regulator of NMD and pre-mRNA splicing, showing its role in hematopoietic differentiation and disease.

This study shows that SRSF1 shuttling between nucleus and cytoplasm is essential for ciliogenesis and development, as demonstrated by phenotypic defects in a mouse model with nuclear-retained SRSF1.

The paper identifies an ER-localized NMD pathway that regulates the stability of ER-translated mRNAs through the interaction of NBAS and UPF1.

This study shows that slow RNAPII elongation causes embryonic lethality and disrupts splicing and gene expression in neural differentiation.

This study reveals how hnRNP A1 binds to the terminal loop of pri-mir-18a, destabilizing stem base-pairing to enhance miRNA processing.