Potent and Broad HIV-1 Neutralization by a Bispecific CD4-CD4i Fusion Protein based on Single-Domain CD4-D1 and X5 CD4i antibody
Xiaojie Chu, Cory Shetler, Zeyu Sun, Chris Perrone, Zhiwei Feng, Kerri J. Penrose, Richard Brad Jones, John W. Mellors, Dimiter Stanchev Dimitrov, Wei Li
The paper designs a bispecific CD4-CD4i fusion protein that broadly neutralizes diverse HIV-1 subtypes with potency comparable to broadly neutralizing antibodies.
bioRxiv · Apr 25, 2026 · PreprintMolecular Biology