Wei Li

Potent and Broad HIV-1 Neutralization by a Bispecific CD4-CD4i Fusion Protein based on Single-Domain CD4-D1 and X5 CD4i antibody

The paper designs a bispecific CD4-CD4i fusion protein that broadly neutralizes diverse HIV-1 subtypes with potency comparable to broadly neutralizing antibodies.

HIV-1 envelopes from virions that persist in plasma on antiretroviral therapy show reduced susceptibility to autologous immunoglobulins and variable sensitivity to broadly neutralizing monoclonal antibodies

The paper examines HIV-1 envelopes from persistent plasma virus on ART, finding reduced autologous Ig neutralization and variable sensitivity to broadly neutralizing mAbs.