John W. Mellors

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

The paper identifies a unique CD8+ T cell population that expands during ART and predicts delayed HIV-1 rebound.

The paper designs a bispecific CD4-CD4i fusion protein that broadly neutralizes diverse HIV-1 subtypes with potency comparable to broadly neutralizing antibodies.

Q4ddPCR improves HIV reservoir quantification by targeting four conserved regions, achieving 95% accuracy and revealing clonal dynamics not detectable by IPDA.

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

The paper uses scRNA-seq to show that monocyte IL1B expression inversely correlates with HIV-1 reservoir size in ART-treated individuals.

The paper examines HIV-1 envelopes from persistent plasma virus on ART, finding reduced autologous Ig neutralization and variable sensitivity to broadly neutralizing mAbs.

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.