ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons
Jacob Aaron Klickstein, Michelle A. Johnson, Pantelis Antonoudiou, Jamie L. Maguire, João A. Paulo, Steven P. Gygi, Chris Weihl, Malavika Raman
This study shows that the p97 R155H mutation impairs lysophagy in motor neurons, leading to lysosomal dysfunction and reduced viability.
Stem Cell Reports · Feb 8, 2024Peer-reviewedNeuroscience