Pantelis Antonoudiou

Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles

The paper shows that specific BLA neurons are recruited by oscillatory states to drive valence-related behaviors.

An Amygdalar Oscillatory Switch Governs Valence Assignment

This study identifies a PV-driven oscillatory switch in the amygdala that governs valence assignment through noradrenergic modulation.

Noradrenergic neuromodulation of cholecystokinin interneurons in the basolateral amygdala alters rhythmic activity and restrains fear memory

The paper shows that NE activates CCK interneurons in the BLA to generate rhythmic inhibitory input, reducing fear memory through enhanced theta oscillations.

Early life stress impairs VTA coordination of BLA network and behavioral states

This study shows that early life stress impairs VTA coordination of BLA network and behavioral states by weakening dopamine signaling between VTA and BLA, leading to increased social avoidance.

Early life stress influences epilepsy outcomes in mice

This study shows that early life stress affects epilepsy outcomes in mice, with sex-dependent effects on seizure susceptibility and mortality.

Sex-dependent effects of early life stress on network and behavioral states.

This study investigates sex-dependent effects of early life stress on network and behavioral states in mice, finding sex-specific alterations in physiology and network activity linked to stress reactivity.

Basolateral amygdala parvalbumin interneurons coordinate oscillations to drive reward behaviors

This study shows that parvalbumin interneurons in the basolateral amygdala coordinate oscillations that drive reward behaviors and are necessary for reward value processing.

ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons

This study shows that the p97 R155H mutation impairs lysophagy in motor neurons, leading to lysosomal dysfunction and reduced viability.

Loss of PV interneurons in the BLA contributes to altered network and behavioral states in chronically epileptic mice

This study shows that loss of PV interneurons in the BLA of chronically epileptic mice leads to altered network and behavioral states, contributing to comorbid anxiety and epilepsy.

Semi-automated seizure detection using interpretable machine learning models

The paper develops a semi-automated seizure detection system using interpretable machine learning models and an open-source tool for improved efficiency and accuracy.

Experience-dependent information routing through the basolateral amygdala

This study shows that prior positive or negative experiences alter the activity of specific BLA neurons, affecting valence processing by biasing information routing.

Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress

This study shows chronic stress impairs endogenous neurosteroid signaling in the BLA, leading to behavioral deficits, and suggests targeting neurosteroidogenesis could be a new treatment for mood disorders.

Sex differences in the alcohol-mediated modulation of BLA network states

This study shows alcohol modulates BLA network states differently in male and female mice, involving δ-GABAARs on PV interneurons, linking alcohol use and anxiety behaviors.

Hypothalamic-pituitary-adrenal axis dysfunction worsens epilepsy outcomes and increases SUDEP risk

This study shows that HPA axis dysfunction in a mouse model increases SUDEP risk and worsens epilepsy outcomes, with potential implications for psychiatric comorbidities.

Miro1-dependent Mitochondrial Dynamics in Parvalbumin Interneurons

This study investigates the role of Miro1 in mitochondrial dynamics of parvalbumin interneurons and shows its impact on neuronal signaling and network synchronization.

Allopregnanolone mediates affective switching through modulation of oscillatory states in the basolateral amygdala

This study shows allopregnanolone modulates oscillatory states in the basolateral amygdala through delta-containing GABAA receptors, contributing to antidepressant effects.

Complementary roles for parvalbumin and somatostatin interneurons in the generation of hippocampal gamma oscillations

This study investigates the roles of parvalbumin and somatostatin interneurons in generating slow and fast gamma oscillations in the mouse hippocampus using optogenetics.