Glucocorticoids reprogram human AML leukemic stem cells to promote elimination through differentiation and apoptosis
Isabella Angela Iasenza, Yi Ling Sun, LeRon Best, Hassan Dakik, Meaghan Boileau, Andrea L. Neumann, Patricia Arreba-Tutusaus, Manon Saby, Josée Hébert, Mark David Minden, Luca Cavallone, Chris Williams, Bertrand Jean-Claude, Kolja Eppert
This study shows glucocorticoids eliminate AML leukemic stem cells by inducing differentiation and apoptosis, with mechanisms involving the glucocorticoid receptor and inflammatory signatures.
bioRxiv · Sep 15, 2026 · PreprintCancer Biology