Josée Hébert

Glucocorticoids reprogram human AML leukemic stem cells to promote elimination through differentiation and apoptosis

This study shows glucocorticoids eliminate AML leukemic stem cells by inducing differentiation and apoptosis, with mechanisms involving the glucocorticoid receptor and inflammatory signatures.

Discovery of compounds targeting human acute myeloid leukemia stem cells via a novel high-throughput screen

This study identifies compounds targeting human AML stem cells through a high-throughput screen and validates their efficacy using xenotransplantation and single-cell RNA sequencing.

TP53-mutant AML with ribosomal gene loss exhibits impaired protein translation and sensitivity to HSP90 inhibition

Predictive Gene Discovery with EPCY: A Density-Based Alternative to DE analysis

EPCY ranks genes by predictive power using cross-validated classifiers and density estimation, outperforming DEG-based methods in selecting robust candidate genes.

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

Replication of a GWAS signal near HLA-DQA2 with acute myeloid leukemia using a disease-only cohort and external population-based controls

The paper replicates a GWAS signal near HLA-DQA2 associated with AML risk using a disease-only cohort and external population-based controls, finding a stronger effect in patients with NPM1 mutations.

SPAT: Surface Protein Annotation Tool

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

Baseline Acute Myeloid Leukemia Prognosis Models using Transcriptomic and Clinical Profiles by Studying the Impacts of Dimensionality Reductions and Gene Signatures on Cox-Proportional Hazard

This paper evaluates how dimensionality reduction techniques and gene signatures affect Cox-Proportional-Hazard models for AML prognosis using the Leucegene dataset.

Target variant detection in leukemia using unaligned RNA-Seq reads

This paper introduces km, a method for detecting targeted mutations in AML using unaligned RNA-Seq reads, showing it is fast, accurate, and limited by sequencing depth.