Kolja Eppert

This study shows that the H3-K27M mutation alters hematopoietic stem cell dynamics and erythroid differentiation, increasing blood cell numbers despite impaired maturation.

This study shows glucocorticoids eliminate AML leukemic stem cells by inducing differentiation and apoptosis, with mechanisms involving the glucocorticoid receptor and inflammatory signatures.

This study identifies compounds targeting human AML stem cells through a high-throughput screen and validates their efficacy using xenotransplantation and single-cell RNA sequencing.

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.