Meaghan Boileau

Glucocorticoids reprogram human AML leukemic stem cells to promote elimination through differentiation and apoptosis

This study shows glucocorticoids eliminate AML leukemic stem cells by inducing differentiation and apoptosis, with mechanisms involving the glucocorticoid receptor and inflammatory signatures.

Discovery of compounds targeting human acute myeloid leukemia stem cells via a novel high-throughput screen

This study identifies compounds targeting human AML stem cells through a high-throughput screen and validates their efficacy using xenotransplantation and single-cell RNA sequencing.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.