Integrity of the minor spliceosome in the developing mouse hypothalamus determines neuronal subtype composition regulating energy balance.
Alisa K. White, Kyle D. Drake, Alexandra E. Porczak, Gabriela Tirado-Mansilla, Madisen F. Lee, Katery C. Hyatt, Chrissy Chow, Tava DeQuattro, Laura E. Mickelsen, Natale R. Sciolino, Alexander C. Jackson, Rahul Kanadia
This study shows that disrupting minor spliceosome function in mouse hypothalamic progenitors leads to altered neuronal subtype composition and obesity due to disrupted energy balance regulation.
bioRxiv · Oct 4, 2022 · PreprintNeuroscience