Alisa K. White

Integrity of the minor spliceosome in the developing mouse hypothalamus determines neuronal subtype composition regulating energy balance.

This study shows that disrupting minor spliceosome function in mouse hypothalamic progenitors leads to altered neuronal subtype composition and obesity due to disrupted energy balance regulation.

Minor intron containing genes: Achilles' heel of viruses?

The paper identifies MIG-encoded proteins as potential pan-viral drug targets, showing that repurposed anti-cancer drugs target these proteins.

Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing

This study shows that Trp53 ablation does not prevent microcephaly in Rnu11 cKO mice, but dKO mice show transcriptomic shifts and more severe cell cycle defects.

The minor and major spliceosome interact to regulate alternative splicing around minor introns

The paper shows that minor and major spliceosomes interact to regulate alternative splicing around minor introns, linking this interaction to disease pathogenesis.