Laura E. Mickelsen

Transcriptional plasticity of melanin-concentrating hormone neurons in the medial preoptic area of lactating mouse dams

The paper reanalyzes single-cell RNA sequencing data to identify two distinct Pmch-expressing neuronal populations in the MPOA of lactating mice, showing lactation-associated transcriptional changes and functional relevance.

A Hypothalamic Circuit that Modulates Feeding and Parenting Behaviors

This study identifies a hypothalamic circuit involving ARCAgRP and MPOABRS3 neurons that modulates the prioritization of feeding and parenting behaviors during lactation.

AgRP neurons coordinate the mitigation of activity-based anorexia

This study identifies AgRP neuron activity as a key factor in activity-based anorexia and shows that activating these neurons can mitigate the condition.

Integrity of the minor spliceosome in the developing mouse hypothalamus determines neuronal subtype composition regulating energy balance.

This study shows that disrupting minor spliceosome function in mouse hypothalamic progenitors leads to altered neuronal subtype composition and obesity due to disrupted energy balance regulation.

Cellular taxonomy and spatial organization of the ventral posterior hypothalamus reveals neuroanatomical parcellation of the mammillary bodies

The paper uses scRNA-seq to classify cell types in the mouse ventral posterior hypothalamus, revealing distinct neuronal and non-neuronal populations and their spatial organization in the mammillary bodies.