Madisen F. Lee

This study shows that disrupting minor spliceosome function in mouse hypothalamic progenitors leads to altered neuronal subtype composition and obesity due to disrupted energy balance regulation.

This study shows that Trp53 ablation does not prevent microcephaly in Rnu11 cKO mice, but dKO mice show transcriptomic shifts and more severe cell cycle defects.

The paper shows that minor and major spliceosomes interact to regulate alternative splicing around minor introns, linking this interaction to disease pathogenesis.