Sirpa Jalkanen

Adenosine impairs T cell function via activation of purine salvage pathway and AMP-induced inhibition of pyrimidine nucleotide biosynthesis

This study shows adenosine impairs T cell function by activating the purine salvage pathway and inhibiting pyrimidine biosynthesis through AMP-mediated suppression of UMP synthase.

CCL5, CLEC11A, IL-7, IL-8, and IL-13: Diagnostic serum biomarkers of gastric cancer identified in a 48-multiplex panel

The paper identifies five serum biomarkers for gastric cancer using a 48-plex panel in a cohort of 239 patients and 48 controls.

Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes

This study identifies changes in lymphatic endothelial cell subsets and increased MGP expression in metastatic sentinel lymph nodes from breast cancer patients.

CXCL12, SCF, and eotaxin are prognostic serum biomarkers in gastric cancer

The paper identifies CXCL12, SCF, and eotaxin as prognostic serum biomarkers for gastric cancer using univariate and multivariate survival analysis.

A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature

This paper uses single-cell transcriptomics to map the transcriptional organization of lymphatic endothelial cells in mouse and human lymph nodes, identifying distinct subsets and their functional roles.

Multivariate genome-wide association analysis of a cytokine network reveals variants with widespread immune, haematological and cardiometabolic pleiotropy

This study identifies genetic variants with pleiotropic effects on cytokines and related traits using a multivariate genome-wide association analysis.

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

This study identifies seven novel genetic loci associated with circulating cytokines and cell adhesion molecules in Finns through GWAS and meta-analysis.

Genome-wide association study identifies 17 new loci influencing concentrations of circulating cytokines and growth factors

This study identifies 17 new genetic loci associated with circulating cytokine and growth factor concentrations in Finns, linking them to immune-related diseases and potential drug targets.

Systems medicine links microbial inflammatory response with glycoprotein-associated mortality risk

This study links elevated glycoprotein acetyls (GlycA) to chronic inflammation and microbial infection risk using integrative omics and health records.