In Utero Exposure to Anti-Caspr2 Antibody Disrupts Parvalbumin Interneuron Function in the Hippocampus
Ciara Bagnall-Moreau, Joshua J. Strohl, Benjamin P. Spielman, Christian Cruz, Patricio T. Huerta, Lior Brimberg
This study shows that in utero exposure to anti-Caspr2 antibodies reduces PV+ interneurons and disrupts inhibitory circuitry in the hippocampus, linking it to ASD-related behavioral impairments.
Brain Behavior and Immunity · Nov 20, 2025Peer-reviewedNeuroscience