Single-Cell Resolution of Cellular Damage Illuminates Disease Progression
Tsimafei Padvitski, Paula Unger Avila, He Chen, Cem Özel, Fabian Braun, Marie-Kristin Kroll, Christian Vossen, Peter Wienand, Linus Butt, David Unnersjö‐Jess, Heike Göbel, Christoph Kuppe, Roman-Ulrich Müller, Pål O. Westermark, Paul T. Brinkkötter, , Andreas Beyer
The paper develops single-cell damage scores to quantify cellular deterioration in degenerative diseases and applies them to murine and human datasets to identify molecular trajectories of damage.
bioRxiv · Feb 20, 2025 · PreprintBioinformatics