Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity
Rianne R. Campbell, Mikah Green, Eric Y. Choi, Andreas B. Wulff, Allison N. Siclair, Smirti Khatri, Geralin Virata, Christina Barrett, Symphanie Key, Samir Patel, Mary Beth Rowell, Daniela Franco, Shanmugasundaram Ganapathy‐Kanniappan, Brian N. Mathur, Mary Kay Lobo
This paper shows that CRISPR-dCas9 systems can cause behavioral and cellular changes in mice even without targeting specific genes, highlighting the need for validation.
eNeuro · Jul 24, 2025Peer-reviewedNeuroscience