Daniela Franco

Nucleus accumbens neuron subtype translatome signatures in socially stress females

The paper identifies female-specific transcriptional changes in nucleus accumbens neuron subtypes under chronic social stress and highlights PI3K-Akt-mTOR signaling as a conserved pathway.

Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity

This paper shows that CRISPR-dCas9 systems can cause behavioral and cellular changes in mice even without targeting specific genes, highlighting the need for validation.

Concurrent maternal stress and THC exposure during pregnancy alters adolescent behavioral outcomes and corticolimbic molecular programs

This study shows that prenatal THC exposure and maternal stress impair maternal behavior and alter offspring neurodevelopment with sex- and region-specific molecular changes.

Inducible CRISPR epigenome systems mimic cocaine induced bidirectional regulation of Nab2 and Egr3

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes

This study identifies molecular and structural changes in nucleus accumbens neuron subtypes during fentanyl abstinence that mediate negative emotional behaviors.

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

This study shows chronic psychosocial stress increases fentanyl consumption in male but not female C57BL/6 mice, with changes in nucleus accumbens Rho GTPases expression.