Mary Kay Lobo

The paper identifies female-specific transcriptional changes in nucleus accumbens neuron subtypes under chronic social stress and highlights PI3K-Akt-mTOR signaling as a conserved pathway.

This study shows that gestational chlorpyrifos exposure increases neuronal activity and 5-HT1B receptor expression in rat somatosensory cortex, leading to persistent hyper-excitation.

This paper shows that CRISPR-dCas9 systems can cause behavioral and cellular changes in mice even without targeting specific genes, highlighting the need for validation.

This study shows that prenatal THC exposure and maternal stress impair maternal behavior and alter offspring neurodevelopment with sex- and region-specific molecular changes.

This study conducts a meta-analysis of mitochondrial DNA copy number in blood samples from individuals with mood disorders, finding increased mtDNAcn in MDD and BD Type II, and decreased in BD Type I.

This study examines transcriptomic changes in reward and sensory brain regions of juvenile mice exposed to perinatal fentanyl, revealing sex-specific gene expression patterns and enriched biological processes.

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

The paper characterizes VP Npas1+ neurons' projections, molecular identity, and role in stress response through RNA-seq and chemogenetic manipulation.

This study identifies Nr4a1's role in cocaine reward by analyzing VP gene expression and manipulating Nr4a1 in specific neurons.

This study identifies molecular and structural changes in nucleus accumbens neuron subtypes during fentanyl abstinence that mediate negative emotional behaviors.

This study shows chronic psychosocial stress increases fentanyl consumption in male but not female C57BL/6 mice, with changes in nucleus accumbens Rho GTPases expression.

This study identifies distinct transcriptomic, physiological, and functional properties of four VP projections and shows their opposing roles in cocaine withdrawal.

This study shows cocaine affects mitochondrial dynamics in neurons by regulating Egr3 transcription of mitochondrial-related genes, with distinct effects in D1-MSNs and D2-MSNs.

This study shows that perinatal fentanyl exposure causes long-term impairments in somatosensory function and behavior in mice, with changes in synaptic and morphological properties.

The paper investigates how TrkB deletion in D1-MSNs leads to stereotypy behavior and identifies molecular and morphological changes in these neurons.

This study shows that perinatal fentanyl exposure in mice leads to somatic withdrawal and lifelong neurobehavioral changes similar to human neonatal opioid withdrawal syndrome.

The paper compares RNAseq methods for analyzing medium spiny neurons in the nucleus accumbens, finding that nuclear-FACS-seq identifies more differentially expressed genes and GWAS hits than other methods.