Eric Y. Choi

Dopamine receptor 1 specific CRISPRa mice exhibit disrupted behaviors and striatal baseline cellular activity

This paper shows that CRISPR-dCas9 systems can cause behavioral and cellular changes in mice even without targeting specific genes, highlighting the need for validation.

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in mice

The paper shows that EV miRNAs from WT mice improve sociability in immunodeficient mice by modulating synaptic function and immune-neuron communication.

Inducible CRISPR epigenome systems mimic cocaine induced bidirectional regulation of Nab2 and Egr3

The paper uses CRISPR tools to mimic cocaine-induced bidirectional regulation of Nab2 and Egr3 in specific NAc MSN subtypes.

Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward

This study identifies Nr4a1's role in cocaine reward by analyzing VP gene expression and manipulating Nr4a1 in specific neurons.

Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes

This study identifies molecular and structural changes in nucleus accumbens neuron subtypes during fentanyl abstinence that mediate negative emotional behaviors.

Glutathione S-transferases: unexpected roles in astrocyte activation and astrocyte-microglia communication during brain inflammation

This study identifies GSTM1's role in astrocyte activation and microglia enhancement during brain inflammation, showing its impact on NF-κB and JNK pathways.