Loss of Bbs8 leads to cystic kidney disease in mice with reduced acetylation of ciliary alpha-tubulin through HDAC2
Emilia Kieckhöfer, Julia Günzler, Peter Andreas Matthiessen, Lena K. Ebert, Christina Klausen, Dagmar Wachten, Metin Cetiner, Max C. Liebau, Thomas R. Benzing, Helen May‐Simera, Bernhard Schermer
This study shows that loss of Bbs8 in mice causes cystic kidney disease by reducing ciliary alpha-tubulin acetylation through increased HDAC2 activity.
bioRxiv · Mar 7, 2024 · PreprintGenetics