Dagmar Wachten

ConvexGating automatically learns unbiased, interpretable gating strategies for flow cytometry data, improving consistency and reducing contamination in cell population identification.

This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

Shiny-Calorie provides a flexible, open-source tool for analyzing and visualizing indirect calorimetry data, supporting standardized integration and statistical analysis of metabolic phenotyping datasets.

This study shows that primary cilia dysfunction in Bbs8-/- mice reduces adipose stem cells and promotes fibrogenic progenitors via disrupted Hedgehog signaling, affecting adipogenesis and lipid uptake.

The paper introduces a photoswitch called DEL-VPR that enables strong, light-induced gene expression in mammalian cells, surpassing constitutive promoters and improving protein production.

The paper develops a fluorescent biosensor (AGMsen) to visualize agmatine dynamics in cells, demonstrating its functionality across neuronal cultures.

This study identifies opposing roles of tissue-resident alveolar macrophages and infiltrating neutrophils/monocyte-derived cells in controlling Legionella longbeachae infection via the IL-18R/IFN-γ/ROS pathway.

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

This study shows that loss of Bbs8 in mice causes cystic kidney disease by reducing ciliary alpha-tubulin acetylation through increased HDAC2 activity.

This paper introduces Metadatasheet, a metadata standard designed to improve data management by aligning with the data-lifecycle and enabling structured metadata recording in Microsoft Excel.

This study investigates the role of Cylicins in spermiogenesis and male fertility using gene-editing in mice and exome sequencing in humans, finding that Cylicin deficiency causes infertility and structural sperm abnormalities.

The paper characterizes motile ciliated cells in zebrafish brain ventricles, showing their developmental origins, functional roles in CSF flow, and impact on ventricular morphology.

This study shows that SRSF1 shuttling between nucleus and cytoplasm is essential for ciliogenesis and development, as demonstrated by phenotypic defects in a mouse model with nuclear-retained SRSF1.