Author

UkJin Lee

Weill Cornell MedicineORCID 0000-0001-6644-4286Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3 Assay:ChIP-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:Hi-C· 2

Frequent Co-Authors

Effie ApostolouiD· 4 shared Alejandra Laguillo-DiegoiD· 2 shared Alexander PolyzosiD· 2 shared Christina S. LeslieiD· 2 shared Matthias StadtfeldiD· 2 shared Abigail LidoskiiD· 1 shared Alexander Martinez‐FundichelyiD· 1 shared Alexander Noor ShoushtariiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMolecular Biology

Effie ApostolouORCID

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4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 10, 2026

KAT6 and KAT7 actively maintain mitotic chromatin composition and acetylation to preserve developmental competence

Alejandra Laguillo-Diego, UkJin Lee, Xiao Liu…·Effie Apostolou

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

DOI 10.64898/2026.11.07.765049

mousehuman

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Cancer BiologyNature GeneticsPeer-reviewedJun 30, 2025

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

Elissa W.P. Wong, Merve Şahin, Rui Yang…·Ping Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

10 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintFeb 13, 2025

Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion

UkJin Lee, Alejandra Laguillo-Diego, Wilfred Wong…·Effie Apostolou

This study shows that cohesin depletion affects locus- and differentiation-specific transcriptional activation and regulatory interactions in mouse ESCs, with some loops and genes being more sensitive than others.

3 citations

mouseChIP-seq

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedDec 5, 2023

Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression

Dylan Murphy, Eralda Salataj, Dafne Campigli Di Giammartino…·Effie Apostolou

51 citationstop 3%

mouseChIP-seq

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