Author

Tuan Trieu

University of Missouri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:Hi-C· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alexander Martinez‐FundichelyiD· 2 shared Ekta KhuranaiD· 2 shared Alexander Noor ShoushtariiD· 1 shared Alexander PolyzosiD· 1 shared Andrew RosowicziD· 1 shared Bing HeiD· 1 shared Changya CheniD· 1 shared Christina Liu· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Alexander Martinez‐FundichelyORCID

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Author profile →

4 papers

Recent·Most cited

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

Elissa W.P. Wong, Merve Şahin, Rui Yang, UkJin Lee, Dan Li, Yingqian Ada Zhan, Rohan Misra, Fanny V. Tomas, Nawaf Alomran, Alexander Polyzos, Cindy J. Lee, Tuan Trieu, Alexander Martinez‐Fundichely, Thomas Wiesner, Andrew Rosowicz, , Ping Chi

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

Nature Genetics · Jun 30, 2025Peer-reviewedCancer Biology

A deep learning approach to predict the impact of non-coding sequence variants on 3D chromatin structure

Tuan Trieu, Alexander Martinez‐Fundichely, Ekta Khurana

This paper introduces DeepMILO, a deep learning model to predict how non-coding variants affect 3D chromatin loops, finding that mutations at loop boundaries are linked to upregulation of BCL2 in lymphoma.

Genome biology · Mar 26, 2020Peer-reviewedBioinformatics

Spatial genome re-organization between fetal and adult hematopoietic stem cells

Changya Chen, Wenbao Yu, Joanna M. Tober, Peng Gao, Bing He, Kiwon Lee, Tuan Trieu, Gerd A. Blobel, Nancy A. Speck, Kai Tan

The paper examines 3D genome organization, epigenome, and transcriptome changes in fetal and adult mouse HSCs, finding stage-specific chromatin interactions and transcription factor roles.

Cell Reports · Dec 1, 2019Peer-reviewedMolecular Biology

Hierarchical Reconstruction of High-Resolution 3D Models of Human Chromosomes

Tuan Trieu, Oluwatosin Oluwadare, Jianlin Jack Cheng

The paper introduces Hierarchical3DGenome, an algorithm that reconstructs high-resolution 3D models of human chromosomes, validated against Hi-C and FISH data.

Scientific Reports · Mar 21, 2019Peer-reviewedBioinformatics