Preclinical Evaluation of Itareparib, a brain penetrant PARP1-selective radioligand, in Glioma Rat Model and Nonhuman Primate
Peng Wen Tan, Nira Hernandez Martin, Claudia Esposito-Zapero, Christina Sun, Takuya Toyonaga, Ming‐Qiang Zheng, Michael Kapinos, Monique Thomas, Syed Faraz Nejati, Clement Korsah, Daniel Holden, Baosheng Chen, Jorge Sepulcre, Richard E. Carson, Yiyun Huang, , Zhengxin Cai
This study evaluates [18F]Itareparib as a PARP1-selective radioligand for PET imaging of gliomas, showing brain penetration and specific tumor uptake in rat models and nonhuman primates.
bioRxiv · Oct 19, 2026 · PreprintCancer Biology