Richard E. Carson

Preclinical Evaluation of Itareparib, a brain penetrant PARP1-selective radioligand, in Glioma Rat Model and Nonhuman Primate

This study evaluates [18F]Itareparib as a PARP1-selective radioligand for PET imaging of gliomas, showing brain penetration and specific tumor uptake in rat models and nonhuman primates.

Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimers disease

This study finds that nucleus basalis of Meynert (Ch4) volume is inversely associated with cortical amyloid burden in cognitively unimpaired adults at varying genetic risk for Alzheimer's disease.

Optimized reference region and the effect on test-retest reliability and detection of Parkinson's disease with UCB-J.

This study evaluates an alternative reference region method for [11C]UCB-J to improve test-retest reliability and Parkinson's disease detection, finding reduced variability and greater effect sizes with a 10mL white matter reference region.

Fetal network controllability co-develops with synaptic development and synchronizes with maternal network controllability during pregnancy

The paper uses network control theory to show fetal brain controllability follows a U-shaped trajectory during pregnancy, co-developing with synaptic functions and synchronizing with maternal controllability changes.

Associations between fluid biomarkers and PET imaging (UCB-J) of synaptic pathology in Alzheimer's disease

The paper examines the relationship between SV2A PET imaging and CSF synaptic protein levels in Alzheimer's disease patients and cognitively normal individuals, finding associations between lower synaptic density and specific protein markers.

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study

This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.

Connecting the Dots: Approaching a Standardized Nomenclature for Molecular Connectivity Combining Data and Literature

The paper introduces a standardized nomenclature for PET-based molecular connectivity and covariance to improve reproducibility and interpretation across imaging modalities and radiotracers.

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Neurotransmitter receptor/transporter PET maps (19 targets, 1239 healthy participants) align with connectomes, explain MEG power, and track cognitive gradients and cortical thinning in 13 disorders.

PET-BIDS, an extension to the brain imaging data structure for positron emission tomography

The paper introduces PET-BIDS, an extension of the BIDS standard for PET data, and provides curated datasets and tools for its use.

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

The paper investigates how molecular and connectomic vulnerabilities contribute to cortical abnormalities across multiple brain disorders using MRI data from 47,000 individuals.

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16

This paper develops and evaluates [18F]SDM-16, a metabolically stable SV2A PET tracer, showing high affinity and specific binding in nonhuman primate brains.