Author

Jorge Sepulcre

Harvard UniversityORCID 0000-0002-4199-2304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 7 Assay:imaging· 6 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Esra SefikiD· 2 shared Federico d’Oleire UquillasiD· 2 shared Ibai Palacio DieziD· 2 shared Jakob SeidlitziD· 2 shared Jesse GomeziD· 2 shared Jonathan D. CoheniD· 2 shared Samuel S.‐H. WangiD· 2 shared Veronica ZhangiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Esra SefikORCID

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Author profile →

8 papers

Recent·Most cited

Preclinical Evaluation of Itareparib, a brain penetrant PARP1-selective radioligand, in Glioma Rat Model and Nonhuman Primate

Peng Wen Tan, Nira Hernandez Martin, Claudia Esposito-Zapero, Christina Sun, Takuya Toyonaga, Ming‐Qiang Zheng, Michael Kapinos, Monique Thomas, Syed Faraz Nejati, Clement Korsah, Daniel Holden, Baosheng Chen, Jorge Sepulcre, Richard E. Carson, Yiyun Huang, , Zhengxin Cai

This study evaluates [18F]Itareparib as a PARP1-selective radioligand for PET imaging of gliomas, showing brain penetration and specific tumor uptake in rat models and nonhuman primates.

bioRxiv · Oct 19, 2026 · PreprintCancer Biology

A protective role for the cerebellum in cognitive aging

Federico d’Oleire Uquillas, Esra Sefik, Jakob Seidlitz, Jewel Merriman, Veronica Zhang, Jonathan D. Cohen, Rafael Romero-García, Varun Warrier, Richard A. I. Bethlehem, Aaron F. Alexander‐Bloch, Jorge Sepulcre, Samuel S.‐H. Wang, Patrizia Vannini, Jesse Gomez

This study investigates the cerebellum's role in cognitive aging using large datasets, finding that cerebellar volume is associated with better cognitive outcomes and protection against decline.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Changes in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first-episode psychosis

Rui He, María Francisca Alonso-Sánchez, Jorge Sepulcre, Lena K. Palaniyappan, Wolfram Hinzen

The paper shows that changes in spontaneous speech structure reflect disrupted cortical hierarchy in first-episode psychosis, linking language and brain organization.

Human Brain Mapping · Sep 20, 2024Peer-reviewedNeuroscience

Structural covariation between cerebellum and cerebral cortex is atypically modulated by thalamus in autism spectrum disorder

Federico d’Oleire Uquillas, Esra Sefik, Bing Li, Matthew A. Trotter, Kara Steele, Jakob Seidlitz, Rowen Gesue, Mariam Latif, Tristano Fasulo, Veronica Zhang, Mikhail Kislin, Jessica L. Verpeut, Jonathan D. Cohen, Jorge Sepulcre, Samuel S.‐H. Wang, Jesse Gomez

The paper investigates structural covariation between cerebellum, thalamus, and cerebral cortex in neurotypical and ASD children, finding altered coupling patterns in ASD.

bioRxiv · Oct 16, 2023 · PreprintNeuroscience

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease

Edmarie Guzmán‐Vélez, Ibai Palacio Diez, Dorothée Schoemaker, Enmanuelle Pardilla‐Delgado, Clara Vila‐Castelar, Joshua T. Fox‐Fuller, Ana Y. Baena, Reisa Anne Sperling, Keith A. Johnson, Francisco Javier Lopera, Jorge Sepulcre, Yakeel T. Quiroz

This study examines how amyloid-β and tau pathologies affect brain functional connectivity in preclinical Alzheimer's disease carriers, finding distinct dysconnectivity patterns in specific brain regions.

Proceedings of the National Academy of Sciences · Apr 5, 2022Peer-reviewedNeuroscience

Transcriptional Signatures of Synaptic Vesicle Genes Define Myotonic Dystrophy Type I Neurodegeneration

Antonio Jiménez-Marín, Ibai Palacio Diez, Garazi Labayru, Andone Sistiaga, María Cristina Caballero, Pol Andrés‐Benito, Jorge Sepulcre, Isidró Ferrer, Adolfo López de Munaín, Jesús M. Cortés

The paper identifies transcriptional signatures of synaptic vesicle genes associated with neurodegeneration in Myotonic Dystrophy Type I using transcriptome and brain imaging data.

Neuropathology and Applied Neurobiology · May 6, 2021Peer-reviewedNeuroscience

Linking lysosomal enzyme targeting genes and energy metabolism with altered gray matter volume in children with persistent stuttering

Ho Ming Chow, Emily O’Dell Garnett, Hua Li, Andrew C. Etchell, Jorge Sepulcre, Dennis T. Drayna, Diane C. Chugani, Soo‐Eun Chang

The paper investigates the relationship between genetic factors and brain structure in children with persistent stuttering, finding spatial correlations between gene expression and gray matter volume differences.

Neurobiology of Language · Jun 5, 2020Peer-reviewedNeuroscience

Altered Sensorimotor-to-Transmodal Hierarchical Organization in Schizophrenia

Debo Dong, Dezhong Yao, Yulin Wang, Seok‐Jun Hong, Sarah Genon, Fei Xin, Kyesam Jung, Hui He, Xuebin Chang, Mingjun Duan, Boris C. Bernhardt, Daniel S. Margulies, Jorge Sepulcre, Simon Bodo Eickhoff, Cheng Luo

This study shows that schizophrenia is associated with a compressed cortical hierarchy organization, reducing the separation between sensory and cognitive systems.

bioRxiv · Mar 6, 2020 · PreprintNeuroscience