Takuya Toyonaga

This study evaluates [18F]Itareparib as a PARP1-selective radioligand for PET imaging of gliomas, showing brain penetration and specific tumor uptake in rat models and nonhuman primates.

This study finds that nucleus basalis of Meynert (Ch4) volume is inversely associated with cortical amyloid burden in cognitively unimpaired adults at varying genetic risk for Alzheimer's disease.

This study evaluates an alternative reference region method for [11C]UCB-J to improve test-retest reliability and Parkinson's disease detection, finding reduced variability and greater effect sizes with a 10mL white matter reference region.

The paper uses network control theory to show fetal brain controllability follows a U-shaped trajectory during pregnancy, co-developing with synaptic functions and synchronizing with maternal controllability changes.

This study investigates the effects of repetitive mild closed-head injury on synaptic density and BOLD-fMRI signal homogeneity in mice, finding decreased synapse density and increased regional homogeneity.

The paper examines amygdalar tau binding and connectivity in preclinical Alzheimer's disease, finding associations with anxiety symptoms.

This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.