Author

Zhengxin Cai

Yale UniversityORCID 0000-0002-2005-6760Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:non-human primate· 2 Research Focus:differential expression· 1 Organism:rat· 1 Assay:snRNA-seq· 1

Frequent Co-Authors

Takuya ToyonagaiD· 3 shared Chao ZhengiD· 2 shared Daniel HoldeniD· 2 shared Ming‐Qiang ZhengiD· 2 shared Richard E. CarsoniD· 2 shared Stephen M. StrittmatteriD· 2 shared Arman Fesharaki‐ZadehiD· 1 shared Austin J. StoneriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Takuya ToyonagaORCID

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Author profile →

4 papers

Recent·Most cited

Preclinical Evaluation of Itareparib, a brain penetrant PARP1-selective radioligand, in Glioma Rat Model and Nonhuman Primate

Peng Wen Tan, Nira Hernandez Martin, Claudia Esposito-Zapero, Christina Sun, Takuya Toyonaga, Ming‐Qiang Zheng, Michael Kapinos, Monique Thomas, Syed Faraz Nejati, Clement Korsah, Daniel Holden, Baosheng Chen, Jorge Sepulcre, Richard E. Carson, Yiyun Huang, , Zhengxin Cai

This study evaluates [18F]Itareparib as a PARP1-selective radioligand for PET imaging of gliomas, showing brain penetration and specific tumor uptake in rat models and nonhuman primates.

bioRxiv · Oct 19, 2026 · PreprintCancer Biology

Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity

Marija Markicevic, Francesca Mandino, Takuya Toyonaga, Zhengxin Cai, Arman Fesharaki‐Zadeh, Xilin Shen, Stephen M. Strittmatter, Evelyn M. R. Lake

This study investigates the effects of repetitive mild closed-head injury on synaptic density and BOLD-fMRI signal homogeneity in mice, finding decreased synapse density and increased regional homogeneity.

Journal of Neurotrauma · Aug 3, 2024Peer-reviewedNeuroscience

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer's Knock-in Mice Require Cellular Prion Protein

Austin J. Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua M. Spurrier, Will Laird, Zhengxin Cai, Stephen M. Strittmatter

This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.

bioRxiv · Feb 15, 2023 · PreprintNeuroscience

A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: Synthesis and preclinical characterization of SDM-16

Chao Zheng, Daniel Holden, Ming‐Qiang Zheng, Richard Pracitto, Kyle C. Wilcox, Marcel Lindemann, Zachary Felchner, Li Zhang, Jie Tong, Krista Fowles, Sjoerd J. Finnema, Nabeel Nabulsi, Richard E. Carson, Yiyun Henry Huang, Zhengxin Cai

This paper develops and evaluates [18F]SDM-16, a metabolically stable SV2A PET tracer, showing high affinity and specific binding in nonhuman primate brains.

European Journal of Nuclear Medicine and Molecular Imaging · Nov 10, 2021Peer-reviewedNeuroscience