Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells
Patrick Nugent, Heungwon Park, Cynthia L. Wladyka, James N. Yelland, Sayantani Sinha, Katharine Y. Chen, Christine Bynum, Grace Quarterman, Stanley Chun-Wei Lee, Andrew Caleb Hsieh, Arvind Rasi Subramaniam
This study uses ReLiC screens to analyze the effects of RNA-associated protein knockouts on RNA metabolism, revealing modular gene network interactions and pathway-specific coupling between growth fitness and mRNA translation.
Nature Methods · May 29, 2025Peer-reviewedMolecular Biology