Stanley Chun-Wei Lee

This study identifies somatic DDX41 mutations as gain-of-function alleles that drive aberrant splicing, particularly of SEPTIN7, contributing to MDS/AML pathogenesis.

This study identifies CDK8 mis-splicing as a driver of altered progenitor fate in SF3B1-mutant MDS, linking splicing defects to transcriptional dysregulation and lineage commitment.

Kompot enables cluster-free differential expression analysis in single-cell data, identifying phenotypic shifts and transcriptional changes across conditions.

This study uses ReLiC screens to analyze the effects of RNA-associated protein knockouts on RNA metabolism, revealing modular gene network interactions and pathway-specific coupling between growth fitness and mRNA translation.