Author

Cynthia L. Wladyka

Fred Hutch Cancer Center

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Molecular Biology· 1

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Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Andrew Caleb HsiehiD· 1 shared Arvind Rasi SubramaniamiD· 1 shared Christine Bynum· 1 shared Grace Quarterman· 1 shared Heungwon ParkiD· 1 shared James N. YellandiD· 1 shared Katharine Y. CheniD· 1 shared Patrick NugentiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperMolecular Biology

Andrew Caleb HsiehORCID

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1 paper

Recent·Most cited

Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells

Patrick Nugent, Heungwon Park, Cynthia L. Wladyka, James N. Yelland, Sayantani Sinha, Katharine Y. Chen, Christine Bynum, Grace Quarterman, Stanley Chun-Wei Lee, Andrew Caleb Hsieh, Arvind Rasi Subramaniam

This study uses ReLiC screens to analyze the effects of RNA-associated protein knockouts on RNA metabolism, revealing modular gene network interactions and pathway-specific coupling between growth fitness and mRNA translation.

Nature Methods · May 29, 2025Peer-reviewedMolecular Biology