Christine Cincotta

Reactivating Hippocampal-Mediated Memories During Reconsolidation to Disrupt Fear

The paper shows that reactivating positive memories during fear memory recall reduces conditioned fear in mice, suggesting a method to disrupt negative affective states through memory updating.

Hippocampal fear engrams modulate ethanol-induced maladaptive contextual generalization in mice.

This study investigates how ethanol exposure affects fear memory processing in mice and shows that optogenetic inhibition of hippocampal engrams reduces maladaptive contextual generalization.

Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse

Chronic activation of fear engrams induces extinction-like behavior in ethanol-exposed mice

This study shows that optogenetic reactivation of fear engrams in ethanol-exposed mice reduces fear responses, mimicking extinction, despite impaired extinction learning.

Chronic optogenetic stimulation of hippocampal engrams variably modulates social behaviors in mice

This study shows chronic optogenetic stimulation of hippocampal engrams in male mice enhances specific social behaviors but not others, with no detectable changes in neural activity markers.