Yosif Zaki

State-dependent geometric transformations in the mouse hippocampus support fear generalization without loss of discriminability

The paper shows that state-dependent geometric transformations in the mouse hippocampus enable fear generalization without losing context discriminability.

Chemotagging: a chemogenetic approach for identifying cell types with in vivo calcium imaging

This paper introduces chemotagging, a method to identify specific cell types in vivo calcium imaging using chemogenetic tools, enabling long-term tracking of neuronal populations.

An anterior hypothalamic circuit gates stress vulnerability

This study identifies an anterior hypothalamic circuit that modulates stress vulnerability by integrating valence signals from the amygdala.

Simultaneous dual-color calcium imaging in freely-behaving mice

This paper introduces a dual-channel miniscope for simultaneous two-wavelength calcium imaging in freely behaving mice, showing spatial coding changes over time.

Development of prefrontal corticostriatal connectivity in mice

This study investigates the development of prefrontal corticostriatal connectivity in mice, showing that axons target their zones early and synapses do not undergo extensive pruning, with Cdh8 playing a role in behavioral outcomes.

Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

The paper introduces a model showing that slow fluctuations in intrinsic excitability drive neural ensemble drift, which is necessary for decoding temporal information.

Aversive experience drives offline ensemble reactivation to link memories across days

This study shows that strong aversive experiences in mice drive offline reactivation of both recent aversive and older neutral memories, linking them across days.

Ensemble-specific deficit in neuronal intrinsic excitability in aged mice

The paper investigates age-related changes in neuronal excitability in the hippocampus of mice, finding that aged mice show a deficit in ensemble-specific excitability after learning, linked to memory impairment.

Reactivating Hippocampal-Mediated Memories During Reconsolidation to Disrupt Fear

The paper shows that reactivating positive memories during fear memory recall reduces conditioned fear in mice, suggesting a method to disrupt negative affective states through memory updating.

Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse

Minian: An open-source miniscope analysis pipeline

Minian is an open-source pipeline for analyzing single-photon in vivo calcium imaging data, offering low memory usage, interactive visualizations, and parameter exploration tools.

Social Reactivation of Fear Engrams Enhances Memory Recall

This study shows that social interactions can reactivate fear memories in male mice, enhancing memory recall through hippocampal engram reactivation.