Author

Christine Leemann

University Hospital Zurich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Karin Jutta MetzneriD· 2 shared Aathma Merin Bejoy· 1 shared Ali MovasatiiD· 1 shared Andreas BrunschweigeriD· 1 shared Helen Louise LightfootiD· 1 shared Jeffrey L. SchloßhaueriD· 1 shared Jochen ImigiD· 1 shared Jonathan HalliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersEvolutionary Biology

Karin Jutta MetznerORCID

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2 papers

Recent·Most cited

Substantial Deceleration of Adaptation of HIV-1 Within 1,500 Generations in an Experimental Evolution: A Genomic Perspective

Ali Movasati, Christine Leemann, Kathrin Neumann, Rongfeng Chen, Lygeri Sakellaridi, Karin Jutta Metzner, Roland R. Regoes

This study tracks HIV-1 adaptation over 1,500 generations in human T-cell lines, finding a substantial deceleration in adaptive mutation fixation rates and fitness gains.

Virus Evolution · Jan 1, 2026Peer-reviewedEvolutionary Biology

Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-viral hsa-miR-132 Processing

Verena Schlösser, Helen Louise Lightfoot, Christine Leemann, Aathma Merin Bejoy, Shashank Tiwari, Jeffrey L. Schloßhauer, Valentina Vongrad, Andreas Brunschweiger, Jonathan Hall, Karin Jutta Metzner, Jochen Imig

This study shows Enoxacin reduces HIV-1 replication by downregulating hsa-miR-132-3p in T-cells, suggesting potential for antiviral therapy through miRNA modulation.

bioRxiv · Nov 10, 2024 · PreprintMolecular Biology