Karin Jutta Metzner

This study shows that retroviral LTRs increase the likelihood of large internal deletions in proviruses, with HIV-1 and HTLV-1 LTRs showing higher deletion rates than HIV-2.

This study identifies DNA damage response proteins that influence the formation of defective HIV-1 proviruses through CRISPR screens and functional validation.

This study tracks HIV-1 adaptation over 1,500 generations in human T-cell lines, finding a substantial deceleration in adaptive mutation fixation rates and fitness gains.

The paper identifies rare twin cysteine residues in HIV-1 Env V1 linked to neutralization escape and breadth development.

This study shows Enoxacin reduces HIV-1 replication by downregulating hsa-miR-132-3p in T-cells, suggesting potential for antiviral therapy through miRNA modulation.

This study evaluates four bioinformatic pipelines for assembling full-length viral genomes, finding that reference sequence similarity affects performance and that runtime and usability vary between tools.

The paper investigates how human genetic variation influences Epstein-Barr virus (EBV) sequence diversity by analyzing paired viral and human genomic data from HIV-coinfected individuals.

V-pipe is a computational pipeline that assesses viral genetic diversity from high-throughput sequencing data by integrating quality control, alignment, mutation calling, and haplotype inference.