JNK regulates β3-containing GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)
Artemis Varidaki, Prasannakumar Deshpande, Elina I. Nagaeva, Annika Schäfer, Christel Sourander, Ye Hong, Soroush Abyari, Valentina Siino, Christoffer Lagerholm, Peter James, Esa R. Korpi, Eleanor T. Coffey
This study shows that JNK1 suppresses β3-containing GABAAR surface expression via GIT1 phosphorylation, affecting inhibitory tone and synaptic function.
bioRxiv · Jan 22, 2025 · PreprintNeuroscience