Contractility governs cardiomyocyte cell cycle activity
Nancy Shehata, Rajiven Srikantharajah, Eleonore Baier, Christoph Manthey, Tim Stüdemann, Marie Nehring, Anita Covic, Christian Müller, Bente Siebels, Paula Nissen, Anika Witten, Magdalena Zafra Castellano, Yago Rodriguez, Lucila Poblano Gómez, Imke Janssen, , Florian Weinberger
This study shows that heart muscle cell contractility suppresses proliferation and that inhibiting it allows cell cycle re-entry, suggesting contractility as a key regulator of cardiac regeneration.
bioRxiv · Aug 19, 2025 · PreprintCell Biology